Could circulating biomarkers of nitrosative stress and protein glycoxidation be useful in patients with gastric cancer?

Background Nitrosative stress leads to protein glycoxidation, but both processes may be strongly related the cancer development. Therefore, aim of this study was assess nitrosative and glycoxidation products in patients with gastric comparison healthy controls. We are also first evaluate diagnostic utility markers respect histopathological classifications (TNM, Lauren’s Goseki’s classification) parameters such as histological type, differentiation grade, presence vascular or neural invasion, desmoplasia Helicobacter pylori infection. Methods The included 50 controls matched for sex age. were measured colorimetrically/fluorometrically plasma serum samples. Student’s t-test Mann-Whitney U-test used statistical analysis. Results NO, S-nitrosothiols, nitrotyrosine, kynurenine, N-formylkynurenine, dityrosine, AGE Amadori significantly increased whereas tryptophan fluorescence decreased compared control. useful diagnosis because they differentiate from individuals high sensitivity specificity. Some determined characterised by AUC value GC according parameters. Conclusions Gastric is associated enhanced circulating glycation. Although further research on a tissue model needed, plasma/serum biomarkers dependent tumour size, invasion depth, lymph node distant metastasis, Thus, stress/protein have potential significance patients.